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Genistein

Genistein
Genistein.svg
Genistein molecule
Names
IUPAC name
5,7-Dihydroxy-3-(4-hydroxyphenyl)chromen-4-one
Other names
4',5,7-Trihydroxyisoflavone
Identifiers
446-72-0 YesY
3D model (Jmol) Interactive image
ChEBI CHEBI:28088 YesY
ChEMBL ChEMBL44 YesY
ChemSpider 4444448 YesY
DrugBank DB01645 YesY
ECHA InfoCard 100.006.524
2826
KEGG C06563 YesY
PubChem 5280961
UNII DH2M523P0H YesY
Properties
C15H10O5
Molar mass 270.24 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
YesY  (what is YesYN ?)
Infobox references

Genistein is an isoflavone that is described as an angiogenesis inhibitor and a phytoestrogen. It was first isolated in 1899 from the dyer's broom, Genista tinctoria; hence, the chemical name. The compound structure was established in 1926, when it was found to be identical with that of prunetol. It was chemically synthesized in 1928.

Isoflavones such as genistein and daidzein are found in a number of plants including lupin, fava beans, soybeans, kudzu, and psoralea being the primary food source, also in the medicinal plants, Flemingia vestita and F. macrophylla, and coffee. It can also be found in Maackia amurensis cell cultures.

Most of the isoflavones in plants are present in a glycosylated form. The unglycosylated aglycones can be obtained through various means such as treatment with the enzyme β-glucosidase, acid treatment of soybeans followed by solvent extraction, or by chemical synthesis. Acid treatment is a harsh method as concentrated inorganic acids are used. Both enzyme treatment and chemical synthesis are costly. A more economical process consisting of fermentation for in situ production of β-glucosidase to isolate genistein has been recently investigated.

Besides functioning as antioxidant and anthelmintic, many isoflavones have been shown to interact with animal and human estrogen receptors, causing effects in the body similar to those caused by the hormone estrogen. Isoflavones also produce non-hormonal effects.


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