Gastrin

GAST
Identifiers
Aliases	GAST, GAS, gastrin
External IDs	OMIM: 137250 MGI: 104768 HomoloGene: 628 GeneCards: GAST
Gene ontology Molecular function • protein binding • hormone activity Cellular component • extracellular region • extracellular space Biological process • response to food • G-protein coupled receptor signaling pathway • signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	2520	14459
Ensembl	ENSG00000184502	ENSMUSG00000017165
UniProt	P01350	P48757
RefSeq (mRNA)	NM_000805	NM_010257
RefSeq (protein)	NP_000796	NP_034387.3 NP_034387
Location (UCSC)	Chr 17: 41.71 – 41.72 Mb	Chr 11: 100.33 – 100.34 Mb
PubMed search

Gastrin
Identifiers
Symbol	Gastrin
Pfam	PF00918
InterPro	IPR001651
PROSITE	PDOC00232
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

2520

14459

ENSG00000184502

ENSMUSG00000017165

P01350

P48757

NM_000805

NM_010257

NP_000796

NP_034387.3
NP_034387

Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas.

Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K⁺/H⁺ ATPase pumps into the apical membrane of parietal cells (which in turn increases H⁺ release into the stomach cavity). Its release is stimulated by peptides in the lumen of the stomach.

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