FOXP2 and human evolution

FOXP2
Available structures PDB Human UniProt search: PDBe RCSB List of PDB id codes 2AS5, 2A07
Identifiers
Aliases	FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2
External IDs	OMIM: 605317 HomoloGene: 33482 GeneCards: FOXP2
Gene ontology Molecular function • DNA binding • sequence-specific DNA binding • protein homodimerization activity • transcription factor activity, sequence-specific DNA binding • metal ion binding • RNA polymerase II core promoter proximal region sequence-specific DNA binding • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding • protein binding • protein heterodimerization activity • RNA polymerase II transcription factor activity, sequence-specific DNA binding • androgen receptor binding Cellular component • nucleus Biological process • positive regulation of epithelial cell proliferation involved in lung morphogenesis • regulation of transcription, DNA-templated • lung development • positive regulation of epithelial cell proliferation • negative regulation of transcription from RNA polymerase II promoter • post-embryonic development • transcription, DNA-templated • cerebellum development • putamen development • growth • vocal learning • positive regulation of mesenchymal cell proliferation • smooth muscle tissue development • cerebral cortex development • caudate nucleus development • camera-type eye development • lung alveolus development • righting reflex • negative regulation of transcription, DNA-templated • skeletal muscle tissue development • forebrain development • response to testosterone • innate vocalization behavior Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	93986	n/a
Ensembl	ENSG00000128573	n/a
UniProt	O15409 Q75MZ5 Q0PRL4 Q8N6B6	n/a
RefSeq (mRNA)	NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900	n/a
RefSeq (protein)	NP_001166237 NP_001166238 NP_055306 NP_683696 NP_683697 NP_683698 NP_001166237.1 NP_683697.2	n/a
Location (UCSC)	Chr 7: 114.09 – 114.69 Mb	n/a
PubMed search		n/a

2AS5, 2A07

93986

n/a

ENSG00000128573

n/a

O15409
Q75MZ5
Q0PRL4
Q8N6B6

n/a

NM_148900

n/a

NP_683698
NP_001166237.1
NP_683697.2

n/a

Forkhead box protein P2 (FOXP2) is a protein that, in humans, is encoded by the FOXP2 gene, also known as CAGH44, SPCH1 or TNRC10, and is required for proper development of speech and language. Initially identified as the genetic factor of speech disorder in KE family, its gene is the first gene discovered associated with speech and language. The gene is located on chromosome 7 (7q31, at the SPCH1 locus), and is expressed in fetal and adult brain, heart, lung and gut.FOXP2 orthologs have also been identified in other mammals for which complete genome data are available. The FOXP2 protein contains a forkhead-box DNA-binding domain, making it a member of the FOX group of transcription factors, involved in regulation of gene expression. In addition to this characteristic forkhead-box domain, the protein contains a polyglutamine tract, a zinc finger and a leucine zipper. The gene is more active in females than in males, to which could be attributed better language learning in females.

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