*** Welcome to piglix ***

CYP2B6

CYP2B6
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450, cytochrome P450 family 2 subfamily B member 6, Cytochrome P450 2B6
External IDs MGI: 88598 HomoloGene: 73894 GeneCards: CYP2B6
Targeted by Drug
ticlopidine
Orthologs
Species Human Mouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_000767

NM_009999

RefSeq (protein)

NP_000758

n/a

Location (UCSC) Chr 19: 40.99 – 41.02 Mb Chr 7: 25.9 – 25.93 Mb
PubMed search

3IBD, 3QOA, 3QU8, 3UA5, 4I91, 4RQL, 4RRT, 4ZV8

NM_000767

NM_009999

NP_000758

n/a

Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the group of enzymes. Along with CYP2A6, it is involved with metabolizing nicotine, along with many other substances.

This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide.


...
Wikipedia

...