B-cell prolymphocytic leukemia | |
---|---|
Prolymphocyte | |
Classification and external resources | |
Specialty | Hematology and oncology |
ICD-O | M9833/3 |
MeSH | D054403 |
B-cell prolymphocytic leukemia is a more aggressive, but still treatable, form of leukemia. The malignant B cells are larger than average. The name is commonly abbreviated B-PLL.
It can involve deletions from chromosome 11 and chromosome 13.
It has been suggested that some cases may represent a variant of mantle cell lymphoma.
It has a relatively poor prognosis.
A case has been described as CD20+, CD22+, and CD5-.
It can also be CD5+.
Another case was described as CD45+, CD19+, CD20+, CD5+, HLA-DR+, CD10-, CD23+/-, CD38+ and FMC7-.
Splenic irradiation has been used in the treatment.