Antidiuretic hormone

AVP
Identifiers
Aliases	AVP, ADH, ARVP, AVP-NPII, AVRP, VP, arginine vasopressin, Vasopressin
External IDs	OMIM: 192340 MGI: 88121 HomoloGene: 417 GeneCards: AVP
Targeted by Drug
, , ,
Gene ontology Molecular function • protein kinase activity • hormone activity • signal transducer activity • cysteine-type endopeptidase inhibitor activity involved in apoptotic process • neurohypophyseal hormone activity • neuropeptide hormone activity • receptor binding • V1A vasopressin receptor binding • V1B vasopressin receptor binding Cellular component • secretory granule • extracellular region • dendrite • cytosol • extracellular space • clathrin-coated vesicle membrane Biological process • sodium-independent organic anion transport • positive regulation of cAMP biosynthetic process • grooming behavior • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • regulation of blood vessel size • response to organic cyclic compound • locomotory behavior • regulation of renal sodium excretion • vasoconstriction • response to testosterone • negative regulation of release of cytochrome c from mitochondria • positive regulation of cytosolic calcium ion concentration • ERK1 and ERK2 cascade • water transport • maternal aggressive behavior • cell-cell signaling • penile erection • response to nicotine • positive regulation of systemic arterial blood pressure • hyperosmotic salinity response • negative regulation of apoptotic process • protein kinase C signaling • generation of precursor metabolites and energy • positive regulation of peptidyl-serine phosphorylation • positive regulation of cell growth • positive regulation of prostaglandin biosynthetic process • positive regulation of gene expression • positive regulation of cellular pH reduction • maternal behavior • positive regulation of vasoconstriction • positive regulation of glutamate secretion • positive regulation of cell proliferation • renal water homeostasis • negative regulation of female receptivity • social behavior • response to ethanol • multicellular organismal water homeostasis • negative regulation of transmission of nerve impulse • signal transduction • apoptotic process • membrane organization Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	551	11998
Ensembl	ENSG00000101200	ENSMUSG00000037727
UniProt	P01185	P35455
RefSeq (mRNA)	NM_000490	NM_009732
RefSeq (protein)	NP_000481	NP_033862.1 NP_033862
Location (UCSC)	Chr 20: 3.08 – 3.08 Mb	Chr 2: 130.58 – 130.58 Mb
PubMed search

551

11998

ENSG00000101200

ENSMUSG00000037727

P01185

P35455

NM_000490

NM_009732

NP_000481

NP_033862.1
NP_033862

Vasopressin, also known as antidiuretic hormone (ADH), is a neurohypophysial hormone found in most mammals. In most species it contains arginine and is thus also called arginine vasopressin (AVP) or argipressin. Its two primary functions are to retain water in the body and to constrict blood vessels. Vasopressin regulates the body's retention of water by acting to increase water reabsorption in the kidney's collecting ducts, the tubules which receive the very dilute urine produced by the functional unit of the kidney, the nephrons.

Vasopressin is a peptide hormone that increases water permeability of the kidney's collecting duct and distal convoluted tubule by inducing translocation of aquaporin-CD water channels in the plasma membrane of collecting duct cells. It also increases peripheral vascular resistance, which in turn increases arterial blood pressure. It plays a key role in homeostasis, by the regulation of water, glucose, and salts in the blood. It is derived from a preprohormone precursor that is synthesized in the hypothalamus and stored in vesicles at the posterior pituitary.

...
Wikipedia