Angiotensin II

AGT

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
4FYS, 1N9U, 1N9V, 2JP8, 2WXW, 2X0B, 3CK0, 3WOO, 3WOR, 4AA1, 4APH, 5E2Q

Identifiers

Aliases

AGT, ANHU, SERPINA8, angiotensinogen

External IDs

MGI: 87963 HomoloGene: 14 GeneCards: AGT

Gene ontology
Molecular function	• type 1 angiotensin receptor binding • hormone activity • superoxide-generating NADPH oxidase activator activity • growth factor activity • type 2 angiotensin receptor binding • protein binding • sodium channel regulator activity • serine-type endopeptidase inhibitor activity • angiotensin receptor binding • receptor agonist activity
Cellular component	• cytoplasm • extracellular region • extracellular exosome • blood microparticle • extracellular space • cytosol
Biological process	• uterine smooth muscle contraction • renal system process • regulation of extracellular matrix assembly • vasoconstriction • positive regulation of cholesterol esterification • positive regulation of catalytic activity • positive regulation of cardiac muscle hypertrophy • phospholipase C-activating G-protein coupled receptor signaling pathway • cell surface receptor signaling pathway • cellular response to mechanical stimulus • blood vessel remodeling • positive regulation of reactive oxygen species metabolic process • stress-activated MAPK cascade • artery smooth muscle contraction • positive regulation of extrinsic apoptotic signaling pathway • regulation of systemic arterial blood pressure by renin-angiotensin • positive regulation of activation of JAK2 kinase activity • regulation of apoptotic process • positive regulation of cellular protein metabolic process • regulation of blood vessel size • negative regulation of neurotrophin TRK receptor signaling pathway • positive regulation of branching involved in ureteric bud morphogenesis • regulation of long-term neuronal synaptic plasticity • positive regulation of renal sodium excretion • kidney development • positive regulation of fibroblast proliferation • cellular sodium ion homeostasis • ERK1 and ERK2 cascade • activation of phospholipase C activity • angiotensin maturation • positive regulation of extracellular matrix constituent secretion • positive regulation of transcription, DNA-templated • positive regulation of blood pressure • negative regulation of cell growth • positive regulation of peptidyl-tyrosine phosphorylation • G-protein coupled receptor signaling pathway • regulation of norepinephrine secretion • positive regulation of inflammatory response • catenin import into nucleus • female pregnancy • positive regulation of protein tyrosine kinase activity • negative regulation of tissue remodeling • regulation of heart rate • regulation of blood pressure • positive regulation of macrophage derived foam cell differentiation • regulation of vasoconstriction • positive regulation of NF-kappaB transcription factor activity • positive regulation of NAD(P)H oxidase activity • nitric oxide mediated signal transduction • G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger • smooth muscle cell proliferation • positive regulation of epidermal growth factor receptor signaling pathway • regulation of blood volume by renin-angiotensin • regulation of cardiac conduction • regulation of calcium ion transport • regulation of transmission of nerve impulse • regulation of blood vessel diameter by renin-angiotensin • cell growth involved in cardiac muscle cell development • regulation of renal sodium excretion • positive regulation of cytokine production • positive regulation of membrane hyperpolarization • response to muscle activity involved in regulation of muscle adaptation • negative regulation of sodium ion transmembrane transporter activity • positive regulation of nitric oxide biosynthetic process • cytokine secretion • angiotensin-mediated drinking behavior • cell-cell signaling • renin-angiotensin regulation of aldosterone production • aging • vasodilation • positive regulation of endothelial cell migration • low-density lipoprotein particle remodeling • regulation of cell proliferation • regulation of cell growth • positive regulation of cell proliferation • fibroblast proliferation • negative regulation of angiogenesis • positive regulation of gap junction assembly • positive regulation of phosphatidylinositol 3-kinase signaling • positive regulation of superoxide anion generation • positive regulation of L-arginine import into cell • positive regulation of L-lysine import into cell • positive regulation of glucose import in response to insulin stimulus • positive regulation of cardiac muscle cell apoptotic process • angiotensin-activated signaling pathway • positive regulation of vascular smooth muscle cell proliferation • positive regulation of cytosolic calcium ion concentration • negative regulation of gene expression • regulation of renal output by angiotensin • negative regulation of endopeptidase activity • positive regulation of vascular associated smooth muscle cell migration • regulation of molecular function
Sources:Amigo / QuickGO

RNA expression pattern

More reference expression data

Orthologs

Species

Human

Mouse

Entrez


183


11606

Ensembl


ENSG00000135744


ENSMUSG00000031980

UniProt


P01019


P11859 Q3UTR7

RefSeq (mRNA)


NM_000029


NM_007428

RefSeq (protein)


NP_000020


NP_031454

Location (UCSC)

Chr 1: 230.7 – 230.71 Mb

Chr 8: 124.56 – 124.57 Mb

PubMed search

4FYS, 1N9U, 1N9V, 2JP8, 2WXW, 2X0B, 3CK0, 3WOO, 3WOR, 4AA1, 4APH, 5E2Q

...
Wikipedia