Amyloid precursor protein

APP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1AAP, 1AMB, 1AMC, 1AML, 1BA4, 1BA6, 1BJB, 1BJC, 1BRC, 1CA0, 1HZ3, 1IYT, 1MWP, 1OWT, 1QCM, 1QWP, 1QXC, 1QYT, 1TAW, 1TKN, 1X11, 1Z0Q, 1ZJD, 2BEG, 2BP4, 2FJZ, 2FK1, 2FK2, 2FK3, 2FKL, 2FMA, 2G47, 2IPU, 2LFM, 2LLM, 2LMN, 2LMO, 2LMP, 2LMQ, 2LOH, 2LP1, 2OTK, 2R0W, 2WK3, 2Y29, 2Y2A, 2Y3J, 2Y3K, 2Y3L, 3AYU, 3DXC, 3DXD, 3DXE, 3GCI, 3IFL, 3IFN, 3IFO, 3IFP, 3JTI, 3KTM, 3L33, 3L81, 3MOQ, 3NYL, 3SV1, 3U0T, 3UMH, 3UMI, 3UMK, 4HIX, 1ZE7, 1ZE9, 2LNQ, 2LZ3, 2LZ4, 2M4J, 2M9R, 2M9S, 2MGT, 2MJ1, 2MPZ, 2MVX, 2MXU, 3BAE, 3BKJ, 3JQ5, 3JQL, 3MXC, 3NYJ, 3OVJ, 3OW9, 4JFN, 4M1C, 4MDR, 4NGE, 4OJF, 4ONF, 4ONG, 4PQD, 4PWQ, 4MVI, 4MVK, 4MVL, 4XXD, 5CSZ, 5AMB, 5AEF, 5AM8, 5BUO, 5HOY, 5HOW, 5HOX, 5KK3, 5C67, 2NAO
Identifiers
Aliases	APP, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, amyloid beta precursor protein
External IDs	OMIM: 104760 MGI: 88059 HomoloGene: 56379 GeneCards: APP
Gene ontology Molecular function • heparin binding • receptor binding • acetylcholine receptor binding • metal ion binding • enzyme binding • peptidase activator activity • peptidase inhibitor activity • protein binding • DNA binding • growth factor receptor binding • PTB domain binding • serine-type endopeptidase inhibitor activity • identical protein binding • transition metal ion binding Cellular component • cytoplasm • endosome • cytosol • trans-Golgi network membrane • membrane • cell-cell junction • synapse • extracellular region • ciliary rootlet • spindle midzone • neuron projection • rough endoplasmic reticulum • dendritic spine • endosome lumen • dendritic shaft • cell surface • terminal bouton • membrane raft • extracellular exosome • integral component of membrane • Golgi apparatus • growth cone • neuromuscular junction • receptor complex • plasma membrane • apical part of cell • astrocyte projection • growth cone lamellipodium • axon • nuclear envelope lumen • clathrin-coated pit • platelet alpha granule lumen • integral component of plasma membrane • main axon • smooth endoplasmic reticulum • ER to Golgi transport vesicle • growth cone filopodium • cytoplasmic vesicle • extracellular space • Golgi lumen • perinuclear region of cytoplasm Biological process • cellular response to nerve growth factor stimulus • amyloid fibril formation • negative regulation of neuron differentiation • neuromuscular process controlling balance • protein phosphorylation • regulation of epidermal growth factor-activated receptor activity • cellular copper ion homeostasis • neuron projection development • cellular response to cAMP • suckling behavior • apoptotic process • locomotory behavior • adult locomotory behavior • positive regulation of mitotic cell cycle • axo-dendritic transport • response to oxidative stress • mRNA polyadenylation • collateral sprouting in absence of injury • ionotropic glutamate receptor signaling pathway • Notch signaling pathway • negative regulation of peptidase activity • smooth endoplasmic reticulum calcium ion homeostasis • synaptic growth at neuromuscular junction • neuron remodeling • dendrite development • extracellular matrix organization • cholesterol metabolic process • mating behavior • cellular response to norepinephrine stimulus • nervous system development • cell adhesion • response to lead ion • regulation of gene expression • positive regulation of G2/M transition of mitotic cell cycle • axon midline choice point recognition • visual learning • cellular protein metabolic process • endocytosis • axonogenesis • regulation of multicellular organism growth • platelet degranulation • positive regulation of peptidase activity • forebrain development • regulation of protein binding • regulation of translation • regulation of synapse structure or activity • cellular process • positive regulation of transcription from RNA polymerase II promoter • negative regulation of endopeptidase activity • response to yeast • antibacterial humoral response • antifungal humoral response • innate immune response • defense response to Gram-negative bacterium • defense response to Gram-positive bacterium • neuron apoptotic process Sources:Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	351	11820
Ensembl	ENSG00000142192	ENSMUSG00000022892
UniProt	P05067	P12023
RefSeq (mRNA)	NM_201414 NM_000484 NM_001136016 NM_001136129 NM_001136130 NM_001136131 NM_001204301 NM_001204302 NM_001204303 NM_201413	NM_001198823 NM_001198824 NM_001198825 NM_001198826 NM_007471
RefSeq (protein)	NP_000475 NP_001129488 NP_001129601 NP_001129602 NP_001129603 NP_001191230 NP_001191231 NP_001191232 NP_958816 NP_958817	NP_001185752.1 NP_001185752 NP_001185753 NP_001185754 NP_001185755 NP_031497
Location (UCSC)	Chr 21: 25.88 – 26.17 Mb	Chr 16: 84.95 – 85.17 Mb
PubMed search

1AAP, 1AMB, 1AMC, 1AML, 1BA4, 1BA6, 1BJB, 1BJC, 1BRC, 1CA0, 1HZ3, 1IYT, 1MWP, 1OWT, 1QCM, 1QWP, 1QXC, 1QYT, 1TAW, 1TKN, 1X11, 1Z0Q, 1ZJD, 2BEG, 2BP4, 2FJZ, 2FK1, 2FK2, 2FK3, 2FKL, 2FMA, 2G47, 2IPU, 2LFM, 2LLM, 2LMN, 2LMO, 2LMP, 2LMQ, 2LOH, 2LP1, 2OTK, 2R0W, 2WK3, 2Y29, 2Y2A, 2Y3J, 2Y3K, 2Y3L, 3AYU, 3DXC, 3DXD, 3DXE, 3GCI, 3IFL, 3IFN, 3IFO, 3IFP, 3JTI, 3KTM, 3L33, 3L81, 3MOQ, 3NYL, 3SV1, 3U0T, 3UMH, 3UMI, 3UMK, 4HIX, 1ZE7, 1ZE9, 2LNQ, 2LZ3, 2LZ4, 2M4J, 2M9R, 2M9S, 2MGT, 2MJ1, 2MPZ, 2MVX, 2MXU, 3BAE, 3BKJ, 3JQ5, 3JQL, 3MXC, 3NYJ, 3OVJ, 3OW9, 4JFN, 4M1C, 4MDR, 4NGE, 4OJF, 4ONF, 4ONG, 4PQD, 4PWQ, 4MVI, 4MVK, 4MVL, 4XXD, 5CSZ, 5AMB, 5AEF, 5AM8, 5BUO, 5HOY, 5HOW, 5HOX, 5KK3, 5C67, 2NAO

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