Agouti-related peptide

AGRP
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HYK, 1MR0
Identifiers
Aliases	AGRP, agouti related neuropeptide, AGRT, ART, ASIP2, AgRP
External IDs	OMIM: 602311 MGI: 892013 HomoloGene: 7184 GeneCards: AGRP
Gene ontology Molecular function • neuropeptide hormone activity • receptor binding Cellular component • Golgi lumen • extracellular region • neuronal cell body • Golgi apparatus • extracellular exosome • extracellular space Biological process • response to insulin • adult feeding behavior • neuropeptide signaling pathway • regulation of feeding behavior • positive regulation of feeding behavior • circadian rhythm • feeding behavior • eating behavior • maternal process involved in female pregnancy • hormone-mediated signaling pathway • long-day photoperiodism Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	181	11604
Ensembl	ENSG00000159723	ENSMUSG00000005705
UniProt	O00253	P56473
RefSeq (mRNA)	NM_001138	NM_001271806 NM_007427
RefSeq (protein)	NP_001129	NP_001258735.1 NP_031453.1 NP_001258735 NP_031453
Location (UCSC)	Chr 16: 67.48 – 67.48 Mb	Chr 8: 105.57 – 105.64 Mb
PubMed search

Agouti protein
Identifiers
Symbol	Agouti
Pfam	PF05039
Pfam clan	CL0083
InterPro	IPR007733
PROSITE	PDOC60024
SCOP	1hyk
SUPERFAMILY	1hyk
OPM protein	1mr0
Available protein structures: Pfam structures PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

1HYK, 1MR0

181

11604

ENSG00000159723

ENSMUSG00000005705

O00253

P56473

NM_001138

NM_001271806
NM_007427

NP_001129

NP_001258735.1
NP_031453.1
NP_001258735
NP_031453

Agouti-related protein (AgRP), also called agouti-related peptide, is a neuropeptide produced in the brain by the AgRP/NPY neuron. It is synthesised only in neuropeptide Y (NPY)-containing cell bodies located in the ventromedial part of the arcuate nucleus in the hypothalamus. AgRP is co-expressed with NPY and acts to increase appetite and decrease metabolism and energy expenditure. It is one of the most potent and long-lasting of appetite stimulators. In humans, the agouti-related peptide is encoded by the AGRP gene.

...
Wikipedia