2016 US Open – Men's Singles
| Men's Singles | |
|---|---|
| 2016 US Open | |
| Champion |
 Stan Wawrinka
|
| Runner-up |
 Novak Djokovic
|
| Final score | 6–7(1–7), 6–4, 7–5, 6–3 |
| Draw | 128 (16Q / 8WC) |
| Seeds | 32 |
Novak Djokovic was the defending champion, but lost in the final to Stan Wawrinka, 7–6(7–1), 4–6, 5–7, 3–6. This was the first time the men's singles champion at the US Open won the match after losing the first set since Juan Martín del Potro in 2009. This was also the first time the men's singles champion at the US Open won the title after being match point down since Djokovic in 2011, with Wawrinka saving match point against Dan Evans in the 3rd round.
This was the first US Open since 1999 not to feature five-time champion Roger Federer. It was also the first Grand Slam tournament since the 2004 French Open in which none of Federer, Rafael Nadal, or Andy Murray reached the semifinals. In addition no American player was seeded inside the top 16 for the first since the introduction of the seeding system in 1930.
Click on the seed number of a player to go to their draw section.
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