Don't miss the special BONUS offer during our Beta-test period. The next 100 new Registered Users (from a unique IP address), to post at least five (5) piglix, will receive 1,000 extra sign-up points (eventually exchangeable for crypto-currency)!

* * * * *    Free Launch Promotions    * * * * *

  • Free Ads! if you are a small business with annual revenues of less than $1M - will place your ads free of charge for up to one year! ... read more

  • $2,000 in free prizes! is giving away ten (10) Meccano Erector sets, retail at $200 each, that build a motorized Ferris Wheel (or one of 22 other models) ... see details

Acquired neuroprotection

Acquired neuroprotection is a synaptic-activity-dependent form of adaptation in the nervous system that renders neurons more resistant to harmful conditions. The term was coined by Hilmar Bading. This use-dependent enhancement of cellular survival activity requires changes in gene expression triggered by neuronal activity and nuclear calcium signaling. In rodents, components of the neuroprotective gene program can reduce brain damage caused by seizure-like activity or by a stroke. In acute and chronic neurodegenerative diseases, gene regulatory events important for acquired neuroprotection are antagonized by extrasynaptic NMDA receptor signaling leading to increased vulnerability, loss of structural integrity, and bioenergetics dysfunction.



Don't forget! that as one of our early users, you are eligible to receive the 1,000 point bonus as soon as you have created five (5) acceptable piglix.